Web18 feb. 2024 · Maribavir is a cytomegalovirus (CMV) pUL97 kinase inhibitor indicated for the treatment of adults and pediatric patients (12 years of age and older and weighing at least 35 kg) with post-transplant CMV infection/disease that is refractory to treatment (with or without genotypic resistance) with ganciclovir, valganciclovir, cidofovir or foscarnet. Web9 dec. 2024 · A dose adjustment of maribavir to 1 200 mg twice daily is recommended when co-administration with these anticonvulsants. Antifungals. ketoconazole. (400 mg …
Takeda’s LIVTENCITY™ (maribavir) Now Available for Certain …
WebMaribavir (Markenname Livtencity) ist ein antiviraler Wirkstoff, der zur Behandlung des Zytomegalievirus (CMV) nach einer Transplantation eingesetzt wird. Maribavir wurde im … Web13 okt. 2016 · Resistance-associated amino acid substitutions (RASs) to maribavir are known to generally map to the pUL97 and pUL27 genes. Genotyping was performed to … how to clean a shirt collar
Pharmacokinetics and Safety Evaluation of Maribavir in Healthy …
Web3 okt. 2024 · At the same time, the benzimidazole l-riboside Maribavir is about to be evaluated in Phase III trials involving transplant recipients with HCMV infections that are refractory or resistant to the currently approved drugs as well as for its potential superiority over Valganciclovir in HSCT patients.Maribavir was developed in the late 1990s and has … WebDescription: Maribavir, also known as 1263W-94; BW-1263W-94; GW-1263; GW-257406X; SHP-620; VP-41263; BW-1263W94, is an UL97 kinase inhibitor potentially for the … WebThe mechanism of action of maribavir is mediated through inhibition of the CMV UL97 gene product. The drug inhibits viral DNA synthesis through blocking of terminal DNA processing. UL97 is involved in the monophosphorylation of ganciclovir and is essential for viral growth. Maribavir has no effect on the metabolism of HIV protease inhibitors. how to clean a shoe brush