Dichloromethane mutagenicity
WebThe kinetic properties of bacterial and rat liver glutathione S-transferases (GST) active with dichloromethane (DCM) were compared. The theta class glutathione S-transferase (rGSTT1-1) from rat liver had an affinity for dihalomethanes lower by three orders of magnitude (K app > 50 mM) than the bacterial DCM dehalogenase/GST from … WebMay 17, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are ... Osamu Endo, Kazuho Inaba, Yukari Totsuka, Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane, Mutagenesis, …
Dichloromethane mutagenicity
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Web1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees working in printing plant in Osaka, Japan. However, few reports have demonstrated an association between these agents and cholangiocarcinoma in rod … WebDichloromethane was originally selected for substance evaluation in order to clarify concerns about: - Carcinogenic - Suspected mutagenic - Suspected reprotoxic - …
WebProduct name : Dichloromethane CAS-No. : 75-09-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 WebTheir mutagenicity was examined with Salmonella typhimurium TA98 in presence or absence of S9 mix. The total mutagenic activity of the acetone extract was 1.8-7.0-fold that of the dichloromethane extract. ... However, the amount of pyrene in the dichloromethane extract was much higher than in the acetone extract. These results indicate that the ...
WebAug 15, 1983 · Four dihalomethanes; dichloromethane, bromochloromethane, dibromomethane and diiodomethane, have been studied with respect to their reactivities … WebJul 1, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions. However, whether the GSTT1-mediated step of t …
WebDichloromethane is no longer produced in Canada (CPI, 2000). From 1977 to 1990, the quantity of dichloromethane imported and used in Canada ranged annually from 9 to 13.2 kilotonnes (Environment Canada, 1990); however, usage of pure dichloromethane, recycled dichloromethane and dichloromethane contained in formulations has …
WebMethylene Chloride is a clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of … incident in cumbernauld yesterdayWebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases Daniel Gisi, Thomas Leisinger & … incident in crayford todayWebMutagenicity: DNA inhibition: Human, Fibroblast = 5000 ppm/1H (Continuous).; Morphological transformation: Rat, Embryo = 160 umol/L.; DNA damage: Oral, rat = 1275 mg/kg.; ... The neurotoxicity is thought to be due to a direct nonspecific CNS depressant action of dichloromethane and to indirect effects of carbon monoxide. … incident in crawleyWebPT.SMART-LAB INDONESIA MSDS – DICHLOROMETHANE Page 2 MATERIAL SAFETY DATA SHEET DICHLOROMETHANE Revision : 02 Date: November 3rd, 2024 MSDS Number : 068 P202 Do not handle until all safety precautions have been read and understood. P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P302 + P352 IF … inbody scanner 270WebMay 4, 2024 · Mulaudzi et al. evaluated the cytotoxicity activities of petroleum ether, dichloromethane, ethanol and water extracts of S. cordatum by evaluating the mutagenicity using the Salmonella /microsome assay using the plate-incorporation procedure with Salmonella typhimurium tester strains TA98, TA100 and TA102 with and … incident in croydonWebMutagenicity Genotoxicity in vivo - rat - Oral DNA damage Embryotoxicity Not Available Specific Target Organ Toxicity-single exposure ... Flammable liquids, toxic, n.o.s. (methanol and dichloromethane), 3, (6.1), pg II . Revised on 09/26/2024 Page 7 of 7 15. REGULATORY INFORMATION TSCA Inventory Status All ingredients are listed on the … incident in construction siteWebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases. The kinetic properties of bacterial … inbody scanner workplace