Cyclophosphamide structure
Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome, granulomatosis with poly… WebDec 18, 2024 · Cyclophosphamide falls under the category of alkalyting agents. Physiochemical Properties Mechanism of Action In those cells of the body which are having low levels of ALDH, cyclophosphamide metabolized to phosphoramide mustard. The metabolite will form cross-linkage between and within the DNA strands at guanine N-7 …
Cyclophosphamide structure
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WebFeb 1, 2024 · Abstract. Cyclophosphamide (CP) is a chemotherapy drug which is widely used in the treatment of neoplastic diseases and have often been detected in urban and … WebCyclophosphamide (CP) has a differential dose-dependent action, an immunosuppressive and immunomodulatory role. ... induction of ESC in mice universally augmented liver enzymes and impaired hepatic structure evidenced by the observed diffuse fatty changes of hepatocytes compared to normal control, in line with the previous studies .
WebCyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations. CAS No. 6055-19-2 Selleck's Cyclophosphamide (NSC-26271) Monohydrate has been cited by 31 publications WebNov 5, 2024 · Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. Cyclophosphamide therapy is associated with minor …
WebApr 10, 2024 · This study aimed to investigate the effect of sea cucumber hydrolysate (SCH) on immunosuppressed mice induced by cyclophosphamide (Cy). Our findings demonstrated that SCH could increase the thymus index and spleen index, decrease the serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, … WebJan 17, 2012 · Cyclophosphamide and ifosfamide are alkylating agents administered to treat malignant disease. They are prodrugs and require activation by hepatic microsomal enzymes before being metabolized to their respective cytotoxic species, phosphoramide mustard and ifosfamide mustard.
WebCyclophosphamide is a nitrogen mustard that acts as alkylating agent . In-vivo, it is splitted into phosphoramide mustard and acrolein by metabolism in the liver. The former is responsible for...
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